Cancer Clinical Research
This is a listing of Loyola University Health System Cancer clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
For more information call (888) LUHS-888.
Cancer
Assessment of Health Behaviors in Cancer SurvivorsTo assess the nutritional and health habits of cancer survivors.
GIDEONThe main purpose of this study is to determine the safety and effectiveness of sorafenib. How the health of participants develops while they are taking sorafenib also will be studied, as will participant satisfaction.
Treatment Therapy Followed by Umbilical Cord Stem Cell TransplantThe primary objective of this study is to measure progression free survival in the elderly at three years after umbilical cord stem cell transplantation, which may include an expanded umbilical cord stem cell unit and using pre-transplant conditioning of fludarabine, cyclophosphamide and total body irradiation.
Cancer: Brain
Chemotherapy and Radiation in Patients Newly Diagnosed With Brain CancerThe purpose of this study is to determine whether the addition of bevacizumab to the standard chemo-radiation will further improve the outcome. This study will find out what effects this change in treatment has on you and on your tumor compared with standard treatment.
Cancer: Breast
A Comparison of the Standard Treatment and an Experimental Treatment for Breast CancerThe purpose of this study is to evaluate which treatment is better for treating breast cancer.
Comparing Different Chemotherapy Regimens to Treat Breast Cancer Before Having SurgeryThe purpose of this study is to compare different chemotherapy treatments and determine which is better for breast cancer patients.
Comparing Different Regimens to Treat Breast Cancer Before SurgeryThe purpose of this study is to learn how breast cancer tumors respond to several different chemotherapy combinations.
Study Comparing Radiation Therapy With or Without Trastuzumab in Women With Early Stage Breast CancerThis purpose of this study is to find out if adding trastuzumab to breast radiation therapy is more effective than radiation therapy without trastuzumab in preventing occurrence of breast cancer in the same breast, in the other breast or in other parts of the body in patients with early stage breast cancer.
Cancer: Head and Neck
Chemotherapy in Patients With Recurrent Head and Neck CancerThe purpose of this study is to compare the effects (good and bad) of the addition of bevacizumab to standard chemotherapy (cisplatin and docetaxel or cisplatin and 5-FU) and to determine if the combination of standard chemotherapy and bevacizumab can increase the effectiveness of treatment for head and neck cancer. This combination is experimental.
Cancer: Leukemia
A Study Comparing the Addition of Midostaurin in the Treatment of Newly Diagnosed Patients Under 60 Years of Age With Acute Myeloid Leukemia (AML)The purpose of this study is to find out if adding midostaurin to cytarabine and daunorubicin is more effective in treating newly diagnosed acute myeloid leukemia patients under the age of 60.
Study Combining Azacitidine With Gemtuzumab Ozogamicin for Patients With Relapsed or Refractory Acute Myeloid LeukemiaThe purpose of this study is to see what effects, good and/or bad, the investigational drug combination of hydroxyurea, azacitidine and gemtuzumab ozogamicin has on acute myeloid leukemia.
Cancer: Lung
Chemotherapy in Individuals With Lung CancerThe primary objective of this study is:
In patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare: a. Overall survival (OS) in the entire study population b. Progression-free survival (PFS) by institutional review in EGFR FISH-positive patients
The secondary objectives are:
In patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare: a. OS and PFS by centralized review in EGFR FISH-positive patients b. PFS by centralized image review and by institutional review in the entire study population
To compare the response rate (confirmed plus unconfirmed, complete and partial responses) in the subset of patients with measurable disease in: a. EGFR FISH-positive patients b. The entire study population
The purpose of this study is to compare the effects, good and/or bad, of cetuximab on lung cancer.
Cancer: Lymphoma
Treatment Therapy Followed by Autologous Stem Cell TransplantThe primary objective of this study is to measure the level of busulfan chemotherapy and adjust the dose for each individual according to the level in the person’s blood during the preparative chemotherapies, followed by autologous hematopoietic stem cell transplant in people with Non-Hodgkin’s lymphoma and Hodgkin’s lymphoma.
Treatment of Patients With Relapsed or Refractory CD30-positive Disease While Completing EKG/ECG MonitoringThis study is being done to test if there are any changes in the ECG/EKG of cancer patients being treated with SGN-35 (brentuximab vedotin).
Cancer: Multiple Myeloma
A Study Investigating the Safety and Efficacy of Combining Three Chemotherapy Drugs as a Preparative Regimen for Multiple Myeloma Participants That Are Eligible for a Peripheral Blood Stem Cell TransplantThe purpose is to study the safety and efficiency of combining busulfan, melphalan and bortezomib as a preparative regimen for autologous hematopoietic stem cell transplant.
Cancer: Ovarian
Comparing Treatments for Ovarian Cancer That Has RelapsedThe purpose of this study is to compare different treatments for ovarian cancer that has relapsed.
Cancer: Ovary, Fallopian Tube, Primary Peritoneal
A Comparison of Different Chemotherapies and Routes of Administration for Ovarian, Fallopian Tube and Primary Peritoneal CancerThe purpose of this study is to determine which chemotherapy regimen is better for the treatment of ovarian, fallopian tube and primary peritoneal cancer.
Cancer: Pancreatic
Chemotherapy in Patients With Pancreatic Cancer That Has Spread to Other Parts of the BodyThe purpose of this study is to determine what effects the experimental drug GDC- 0449 has on your type of cancer.
Cancer: Renal/Kidney
Chemotherapy in Patients Who Have Cancer of the Kidney That Has Spread to Other Organs of the BodyThe purpose of this study is to compare the safety and effectiveness of the study drug Everolimus given before sunitinib versus sunitinib given before the study drug Everolimus, to determine the most effective order to give sunitinib and Everolimus to slow tumor growth and to determine which study treatment schedule has less side-effects.
Cancer: Uterus
Comparison of a Combination of Chemotherapy Drugs to the Standard Chemotherapy Treatment for Uterine CancerThe purpose of this study is to compare a different chemotherapy combination with the current standard chemotherapy treatment for uterine cancer.
Cancer: Bone
Bone Health in the Jaw of Cancer PatientsThe purpose of this study is to learn how often ONJ occurs in participants who cancer has spread to the bone and are being treated with zoledronic acid during a three-year time period after starting treatment. This study will also identify risk factors associated with ONJ.
Cancer: Brain
A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastomaThe purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.
Cancer: Breast
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancerThe purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
Breast Cancer and Hormone Suppression StudyThe research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.
Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.
Comparing Different Treatments for Breast Cancer ParticipantsThis study will determine which treatment is better for certain breast cancer participants.
Medication Study for Hormone Receptor Positive Advanced Breast CancerThe purpose of this research is to study the effects (good and bad) of a new anti-cancer drug called lapatinib when added to an anti-estrogen drug called fulvestant for the treatment of advanced breast cancer.
Pathological Studies on Breast Cancer TissueThe purpose of the study is to analyze tumor specimens from breast cancer participants.
Preventing Neuropathy During Certain Breast Cancer Chemotherapy TreatmentsThe purpose of this study is to determine if the study drug prevents neuropathy of certain breast cancer chemotherapy treatments.
Recurrent Breast Cancer StudyThe purpose of this study is to determine how effective combining carboplatin, ABI-007 and bevacizumab are in the advanced breast cancer.
SOFT TrialThe purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.
Study Between Lapatinib and Trastuzumab for Participants With Breast CancerThe main purpose of ALTTO is to find out whether lapatinib is effective in preventing cancer from returning and in extending survival in participants with HER2-positive breast cancer.
Study Using Two Investigational Drugs for Breast Cancer Participants Who Have Progressed While Receiving Prior TherapyTo determine how safe and tolerable the combination of the two investigational drugs are in certain breast cancer participants.
Treatment for Metastatic Breast Cancer with Anastrozole with or without FulvestrantThe purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.
Trial Comparing the Combinations of Medications Administered Prior to Breast Cancer SurgeryThe purpose of this study is to determine if combining two drugs, lapatinib and trastuzumab, with the chemotherapy drug paclitaxel before surgery increases tumor shrinkage in the breast.
Cancer: Cervical or Endometrial
Endometrial or Cervical Cancer Radiation Therapy StudyThe purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.
Cancer: Cervix
Comparing Certain Chemotherapy Treatments for Cervical CancerThe purpose of this study is to determine which chemotherapy treatment results in improved overall survival.
Cancer: Colorectal
Chemotherapy (either FOLFOX or FOLFIRI) in Combination With Avastin in Patients With Locally-advanced or Metastatic Colorectal CancerThis study is being done to evaluate if pegfilgrastim is needed to stop the white blood cells from decreasing too much during your cancer treatment and to evaluate the effect, if any, of pegfilgrastim on your progression-free and overall survival.
Cancer: Gallbladder or Bile Duct
Chemotherapy and Radiation for Participants With Cancer in the Bile Duct or GallbladderThe purpose of this study is to find out what effects, good and/or bad, capecitabine, gemcitabine and radiation have on you and your cancer of the bile duct or gallbladder.
Cancer: Kidney (Renal)
Measurement of Bone Strength to Help Predict Bone Fracture Risk While Taking SorafenibThe purpose of this study is to measure bone strength in order to help predict bone fracture risk while taking the study drug sorafenib and to learn whether sorafenib treatment has an effect on the heart pumping blood properly.
Cancer: Leukemia
A Study Evaluating the Safety and Efficacy of Combining Two Drugs for Participants Age 60 and Older on Previously Untreated Acute Myeloid LeukemiaThe purpose of this study is to find out the safety and efficacy of combining two drugs, azacitidine and gemtuzumab ozogamicin, to treat participants age 60 or older for untreated acute myeloid leukemia.
Leukemia Relapse TrialThe purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.
Cancer: Lung
Additional Chemotherapy Drug after surgical removal of Non Small Cell Lung CancerThe purpose of this study is to determine if adding the new drug bevacizumab to chemotherapy improves the chance for cure for patients who have had surgery for the removal of the lung cancer and to compare the effects (good and bad) of adding bevacizumab to chemotherapy compared to standard chemotherapy alone. Bevacizumab works by preventing the formation of new blood vessels, including those that surround and supply cancer cells, with the oxygen and nutrients they need to survive and grow.
Chemotherapy Agents in Patients With Lung Cancer That Has Grown Despite Earlier Treatment With ChemotherapyThe purpose of this study is to compare the effects, good and/or bad, of topotecan alone with topotecan plus AVE0005 to find out which is better. We would also like to find out more about the effects, good and/or bad, that weekly topotecan causes.
Lung Cancer Medication Study, with or without chemotherapy, after lung cancer surgeryThis study is testing to see if giving an oral medication (erlotinib) to early stage lung cancer patients who have had surgery to remove their tumors will keep the cancer from coming back. The tumors will be tested and must contain certain growth factors in order for you to participate in the study.
Medication Comparison for Women with Advanced Non-Small Cell Lung CancerThe investigational drug for this study (CT-2103) was designed to improve the delivery of the chemotherapy drug to tumor tissue while protecting normal tissue from toxic side effects. This study is designed to test whether CT-2103 with carboplatin can prolong life longer than paclitaxel with carboplatin.
Mineral Therapy After Lung Cancer SurgeryThis research is being done to study whether taking selenium (a mineral) can prevent the development of second lung cancers.
Radiation Therapy in Patients With Lung Cancer That Has Spread to Other Parts of the Body.The purpose of this study is to:
• Find out if radiation therapy improves the survival of patients with your type of cancer, when given after chemotherapy. • Find out what effects (good and bad) that radiation therapy after standard chemotherapy has on you and your cancer.
Cancer: Lymphoma
A Study to Investigate the Effects of SGN-35 on Your Heart Rate and Heart RhythmThe purpose of this study to investigate the effects of SGN-35 on your heart rhythm.
Chemotherapy Treatments for Diffuse Large B-cell Lymphoma.The purpose of this study is to compare the effects (good and bad) of two treatments for lymphoma. The treatments are known as R-CHOP and DA-EPOCH-R. Another goal of the study is to analyze your tumor using new scientific laboratory studies to better understand your type of lymphoma.
Chemotherapy for Relapsed/Refractory Non-Hodgkin's Lymphoma.The purpose of this study is to compare galiximab given with rituximab or with rituximab alone to determine what effects (good or bad) galiximab has on you, and to determine how galiximab and rituximab are broken down by your body.
Evaluation of Treatments for Newly Diagnosed Burkitt’s and Burkitt-like LymphomaThe primary objective of this study is to evaluate the effects of two different chemotherapy treatment regimens in patients with Burkitt’s and Burkitt-like lymphoma
Evaluation of Cisplatin Plus Etoposide Plus Gemcitabine Plus Solumedrol (PEGS) in Peripheral T-Cell Non-Hodgkin’s LymphomaThe purpose of this study is to find out what effects (good and bad) the combination of cisplatin, etoposide, gemcitabine, and solumdrol (PEGS) has on you and your lymphoma.
Medication Study for Relapsed Hodgkins LymphomaThis study is for people with relapsed or refractory Hodgkins lymphoma. The purpose is to see what effects (good and bad) a drug called temsirolimus has on you and your lymphoma.
Treatment Therapy Followed by Stem Cell Transplant for Relapsed Follicular Non-Hodgkin’s LymphomaThe primary objective of this study is to measure progression-free survival at two years after allogeneic hematopoietic stem cell transplantation (HSCT) using pre-transplant conditioning of fludarabine, cyclophosphamide and rituximab (FCR) for patients with relapsed follicular non-Hodgkin’s lymphoma.
Treatment for Participants with Advanced Follicular Non-Hodgkin’s LymphomaThe purpose of the study is to evaluate your response (good and bad) of receiving R-CHOP and tositumomab followed by maintenance treatment for participants with follicular non-Hodgkin lymphoma.
Treatment of Aggressive Hodgkin Lymphoma Based on PET Scan ResultsThis study will follow PET scan results to determine if your disease is responding to standard treatment for your Hodgkin lymphoma. If it is not responding, you will be switched to a more intensive treatment plan.
Treatment of Relapsed Mantle Cell Non-Hodgkin’s Lymphoma With LenalidomideThe purpose of this study is to see what effects (good and bad) a drug called lenalidomide has on you and your lymphoma.
Treatment of relapsed or refractory ALCLThis study is being done to test if SGN-35 (treatment drug) has an effect on cancer in patients with ALCL.
Cancer: Prostate
A Study Evaluating Early Treatment With Zoledronic Acid for Men With Prostate CancerThe purpose of this study is to determine if early treatment with zoledronic acid delays bone problems for men with prostate cancer involving the bone.
Cancer: Rectal
A Combination of Chemotherapy (Including Cetuximab), Radiation Therapy and Surgery for Participants With Stage II or III Rectal CancerThe purpose of this study is to find out what effects, good and/or bad, the combination of the chemotherapies, radiation therapy and surgery has on the participant and their rectal cancer.
Cancer: Skin (Melanoma)
Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.
Cancer: Soft Tissue Sarcoma
Chemotherapy Study for Sarcoma PatientsThis study will determine the benefit of an investigational drug (AVE8062), which is an antivascular treatment that works by destroying the small vessels that feed the tumor with blood, for patients with soft-tissue sarcoma whose treatments with anthracycline and ifosfamide have failed.
Cancer:Gastric and gastroesophageal junction (GEJ)
Chemotherapy in Patients With Advanced Stomach CancerThe purpose of this study is to find out what effects GDC-0449 in combination with FOLFOX chemotherapy has on you and your gastroesophageal adenocarcinoma cancer.
Cardiovascular Health: Heart Failure
Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritede in Subjects with Decompensated Heart Failure (ASCEND-HF)This study is being done to find out if the drug that is being researched, nesiritide (tradename Natrecor®)? as compared to placebo (pill with an inactive substance which looks like the real drug), plus the usual treatment for acute decompensated heart failure (standard of care) helps:· improve your breathing difficulties· reduce the chance that you will be readmitted to the hospital· patients live longer
Transplant: Lung
Lung Transplant: Does Cyclosporine Inhaled Solution Help Prevent the Rejection?The purpose of this study is to determine whether inhaled cyclosporine (CIS), in addition to other medications that put down the immune system, helps prevent a new lung(s) transplant from being rejected by the body’s natural defense system.